Groundbreaking study by Texas Biomed scientists shows drugs significantly reduce TB progression

Groundbreaking study by Texas Biomed scientists shows drugs significantly reduce TB progression

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Importantly, this occurs inside granuloma structures, dense cellular clusters that the body forms to try to stop Mtb. Builds around. Antibiotics and other treatments have great difficulty penetrating granulomas, which is one reason why M.T.B. It’s so hard to eliminate.

“Immunotherapy is a game in the field of cancer by finding ways to help a patient’s own immune system fight tumors more effectively,” said Larry Schlesinger, MD, Texas BioMed professor, president and CEO and senior paper author Larry Schlesinger, MD, a Texas Biomed professor and senior paper author. -She’s been a changer. “We believe that, similarly, host-directed therapy could be a game-changer for infectious diseases.”

The research team, led by Texas BioMed staff scientist Eusondia Arnett, PhD, tested MCL-1 and BCL-2 inhibitors individually, together, and in combination with TB antibiotics to see how TB growth was affected . The use of both inhibitors was more effective in limiting the growth of TB than either one or the other; And combining them with antibiotics was far more effective than the inhibitors or antibiotics alone.

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