De Bruyne replaces Amadou Onana, who ruptured his anterior cruciate ligament against the United States.
Jérémy Doku also started for Belgium, with Dodi Luukbakio left on the bench.
Lineup:
Spain: Unai Simon; Pedro Porro, Pau Cubersi, Aymeric Laporte, Marc Cucurella; Rodri, Fabian Ruiz, Dani Olmo; Lamin Yamal, Alex Baena, Mikel Oyarzabal.
Belgium: Thibaut Courtois; Brandon Mechele, Maxime De Cuyper, Timothy Castagne, Nathan Ngoy; Kevin De Bruyne, Youri Tielemans, Nicolas Raski;, Leandro Trossard, Charles de Ketelair, Jeremy Doku.