And they will have to score these runs without star batsman Steve Smith, who was out due to vertigo.
After losing the toss in the match, Australia were finding it difficult to get wickets initially, where a win would have assured them a place in the semi-finals.
But Zadran and Rashid Khan (35 not out) stitched an unbroken partnership of 58 runs from 28 balls to keep Afghanistan in the race for the semi-finals after four wins from seven matches.
Mitchell Starc suffered the loss, with Rashid hitting him for two sixes in the last over – the first flying over long-off, despite bending down, he still hit a sharp shot over square leg with his left hand.