The foundation's website says it has spent $53.8 billion since 2000 and claims to have halved the number of children worldwide dying before their fifth birthday in that time.
Bill Gates on Monday thanked his ex-wife for her “significant contributions” to the organization.
“As a co-founder and co-chair, Melinda has played a key role in shaping our strategies and initiatives, making a significant impact on global health and gender equality,” he said.
“I'm sad to see Melinda go, but I'm sure she will have a huge impact on her future philanthropic work.”
The organization's chief executive, Mark Suzman, said it would be renamed simply the Gates Foundation.
“I really admire Melinda, and the important role she has played in starting the Foundation and establishing our values has underpinned everything we have achieved over the last 24 years,” he said in a video posted. “He has played an essential role in that.” social media.
“I will miss working with him and learning from him. I look forward to seeing his continued impact.”