César Azpilicueta signed from Chelsea, with Turkey’s Caglar Soyuncu coming from Leicester and left-back Javi Gallan from Celta Vigo.
Joao Felix, the club’s record signing in 2019, is not seen as part of coach Diego Simeone’s plans following his return from an unsuccessful loan spell at Chelsea, and is expected to be dropped.
Real Sociedad, who have qualified for the Champions League, have brought in Portugal forward Andre Silva on loan following the retirement of Spain great David Silva following a serious knee injury during pre-season.
Villarreal, who finished fifth last term, look set to rebuild after losing Nicolas Jackson and Pau Torres to the Premier League and Samuel Chukwueze to AC Milan.
Granada is back in the top flight after securing promotion at the first attempt with play-off winners Alavés, with Las Palmas returning after a five-year absence.