Brook completed his maiden century off only 80 balls, capping a highly entertaining day for a crowd of 6,000, which included approximately 150 “Barmy Army” fans.
Brook added 176 runs with Pope for the fourth wicket, which fell to fast bowler Muhammad Ali.
Pakistan struggled for a while in the second session when they dismissed Duckett, Crawley and Joe Root (23) inside a 53-run stand but fell short.
Debutant leg-spinner Zahid Mahmood was Pakistan’s most successful bowler with 2-160 on a pitch similar to the one used against Australia earlier this year.
After scoring 1,187 runs for the loss of just 14 wickets in five days that pitch was declared “below average” by the match referee.
Duckett, who scored his maiden century after being recalled to the Test side after a six-year absence, missed a reverse sweep off Mahmood and was trapped leg before.
West Indies umpire Joel Wilson initially ruled it not out, only to change his decision on review by Pakistan.
Duckett, who hit 15 boundaries, put on 233 for the first wicket with Crawley – an England record for the first wicket against Pakistan.