It also has a strong chance of winning Best Actor for Cillian Murphy, who is locked in a tight race with 'The Holdovers' Paul Giamatti.
And if the film – based on the biography of Pulitzer Prize winner J. Robert Oppenheimer – wins Best Adapted Screenplay, the win could be huge.
“I went to almost every 'Oppenheimer' this year,” said one Oscar voter, who asked to remain anonymous as Academy members are instructed not to discuss their ballots.
“It was a huge cinematic achievement… This is the year of 'Oppenheimer',” Voter told AFP. Elsewhere, the competition for Best Actress promises to be prickly.
Emma Stone, who previously won an Academy Award for 'La La Land', is considered one of the finest actors of her generation. She gives a brilliant, courageous performance in 'Poor Things'.
But 'Killers of the Flower Moon's Lily Gladstone doesn't just have the influence of her director Martin Scorsese, she also has the weight of history behind her. She is trying to become the first Native American to win an acting Oscar.
